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2-Chloro-5-fluoropyrimidine CAS 62802-42-0
Product Code B2391-5g
Price £100 ex. VAT
£ GBP

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A fluorinated pyrimidine building block

Applied as a synthesis intermediate for APIs and OLEDs

5-Fluoro-2-chloropyrimidine (CAS number 62802-42-0) is derived from pyrimidine, an aromatic heterocyclic 6-membered ring with two nitrogen atoms at positions 1 and 3. 5-Fluoro-2-chloropyrimidine also has a fluorine and a chlorine substituents at the para-position, making it useful for synthesizing linear molecules. With two nitrogens in the ring, 5-fluoro-2-chloropyrimidine is π electron deficient which facilitates nucleophilic aromatic substitution. 2-Chloro-5-fluoropyrimidine is often used to synthesize active pharmaceutical ingredients (APIs), such as antibiotics.

5-Fluoro-2-chloropyrimidine is also used to synthesize ligands for iridium complexes. The iridium complexes show great external quantum efficiency exceeding 29.5%.

Multiple functional groups

Multiple functional groups

For facile synthesis

Fluorinated building block

Fluorinated pyrimidine building block

For drug discovery, organometallic ligands and semiconducting materials

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High purity 62802-42-0

High purity

>98% High purity

General Information

CAS Number 62802-42-0
Chemical Formula C4H2ClFN2
Full Name 2-Chloro-5-fluoropyrimidine
Molecular Weight 132.52 g/mol
Synonyms 5-Fluoro-2-chloropyrimidine
Classification / Family Fluorinated building block, Heterocyclic building block, APIs, OLEDs

Chemical Structure

2-Chloro-5-fluoropyrimidine chemical structure, CAS 62802-42-0
2-Chloro-5-fluoropyrimidine chemical structure, CAS 62802-42-0

Product Details

Purity 98%
Boiling Point Tb = 172 – 174 °C at 760 mmHg
Relative Density 1.073 g/mL at 25 °C
Appearance Colourless liquid

MSDS Documentation

2-Chloro-5-fluoropyrimidine2-Chloro-5-fluoropyrimidine MSDS Sheet

Literature and Reviews

  1. Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist, W. Karstens et al., Bioorg. Med. Chem., 84, 117258(2023); DOI: 10.1016/j.bmc.2023.117258.
  2. Novel pyrimidine-piperazine hybrids as potential antimicrobial agents: in-vitro antimicrobial and in-silico studies, S. Rejinthala et al., Results in Chemistry, 5, 100951(2023); DOI: 10.1016/j.rechem.2023.100951 .
  3. Synthesis, evaluation, and mechanism study of new tepotinib derivatives as antiproliferative agents, N.-N. Zhang et al., Molecules, 24, 1173(2019); DOI: 10.3390/molecules24061173.
  4. Green iridium complexes based on pyrimidine derivatives for efficient electroluminescence with EQE near 30%, H.-B. Han et al., Dyes Pigm., 160, 863–871(2019); DOI: 10.1016/j.dyepig.2018.09.017.
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