2-Fluoroadenine

CAS Number 700-49-2

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

A fluorinated adenine

Strong biological interaction for anti-cancer, fluorine probe and hydrogels

Overview
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2-Fluoroadenine (CAS number 700-49-2) is a fluorinated heterocyclic aromatic compound consisting of fused pyrimidine and imidazole rings. Adenine is one of the four nucleobases in the nucleic acids of deoxyribonucleic acid (DNA). Adenine derivatives, such as adenosine triphosphate (ATP), are vital organic compounds in human body. In recent anti-cancer study, 2-fluoroadenine acts as a radiosensitizer that damages the DNA in cancerous cells under low energy electron (20 eV) radiation. As a fluorinated compound, 2-fluoroadenine has been used as a fluorine probe in ¹⁹F NMR for studying the conformational exchange in neomycin sensing riboswitch.

A thermoreversible hydrogel is prepared from adenine and 1,3,5-tris(4-carboxyphenyl)benzene in water. The hydrogel can capture dyes like methylene blue, rhodamine 6G and crystal violet in application of water purification.

Multiple functional groups

For facile synthesis

Fluorinated adenin building block

For drug discovery, NMR probe and hydrogels

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	700-49-2
Chemical Formula	C₅H₄FN₅
Full Name	2-Fluoroadenine
Molecular Weight	153.12 g/mol
Synonyms	2-Fluoro-7H-purin-6-amine, 2-Fluoro-6-aminopurine
Classification / Family	Fluorinated building block, Heterocyclic building block, APIs, Radoisensitizers, Hydrogels

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m > 350 °C
Appearance	White powder

MSDS Documentation

2-Fluoroadenine MSDS Sheet

Literature and Reviews

Multi-site conformational exchange in the synthetic neomycin-sensing riboswitch studies by ¹⁹F NMR, J. Overbeck et al., Angew. Chem. Int. Ed., 2023, 62, e202218064, DOI: 10.1002/anie.202218064.
Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient-derived xenografts, R. Rab et al., Cancer Rep., 6(2), e1708(2023); DOI: 10.1002/cnr2.1708.
Lab-on-a-DNA origami: nanoengineered single-molecule platforms, S. Kogikoski et al., Chem. Commum., 59, 4726(2023); DOI: 10.1039/d3cc00718a.
Discovery of ureido-based apcin analogues as Cdc20-specific inhibitors against cancer, Y. He et al., Pharmaceuticals, 16, 304(2023); DOI: 10.3390/ph16020304.
Removal of toxic dyes from aqueous medium using adenine based bicomponent hydrogel, P. Sukul et al., RSC Advances, 3, 1902(2013); DOI: 10.1039/c2ra22988a.

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